Article
Detection of APC mutations in fecal DNA from patients with colorectal tumors.
The New England journal of medicine - 31 Jan 2002
Traverso Giovanni, Shuber Anthony, Levin Bernard, Johnson Constance, Olsson Louise, Schoetz David J, Hamilton Stanley R, Boynton Kevin, Kinzler Kenneth W, Vogelstein Bert
Abstract excerpt
BACKGROUND: Noninvasive methods for detecting colorectal tumors have the potential to reduce morbidity and mortality from this disease. The mutations in the adenomatous polyposis coli (APC) gene that initiate colorectal tumors theoretically provide an optimal marker for detecting colorectal tumors. The purpose of our study was to determine the feasibility of detecting APC mutations in fecal DNA with the use of...
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