Article
Detection and quantification of mutations in the plasma of patients with colorectal tumors.
Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 2005
Diehl Frank, Li Meng, Dressman Devin, He Yiping, Shen Dong, Szabo Steve, Diaz Luis A, Goodman Steven N, David Kerstin A, Juhl Hartmut, Kinzler Kenneth W, Vogelstein Bert
Abstract excerpt
The early detection of cancers through analysis of circulating DNA could have a substantial impact on morbidity and mortality. To achieve this goal, it is essential to determine the number of mutant molecules present in the circulation of cancer patients and to develop methods that are sufficiently sensitive to detect these mutations. Using a modified version of a recently developed assay for this purpose, we...
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