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Article

Screening for APC mutations based on detection of truncated APC proteins.

Digestive diseases and sciences - 1 Feb 1998

Tominaga O, Nita M E, Nagawa H, Muto T

Abstract excerpt

Mutation of the adenomatous polyposis coli (APC) gene is frequently found in colorectal tumors from both familial adenomatous polyposis (FAP) and non-FAP patients. Analysis of APC mutation is time-consuming and costly due to the large size of the APC gene. As the majority of APC mutations result in the truncation of gene products, the detection of truncated APC proteins may be used as a screening method for APC...

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Share to Blotting, Western
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

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Source

Identifiers

PMID: 9512122
DOI: 10.1023/a:1018846103834

Genes

APC
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Screening for APC mutations based on detection of truncated APC proteins.PMID 9512122Read ↗

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Detection of APC mutations in fecal DNA from patients with colorectal tumors.Semantic proximity Read ↗

[Current data on the role of APC protein in the origin of colorectal cancer].Semantic proximity Read ↗

Phenotypic differences in familial adenomatous polyposis based on APC gene mutation status.Semantic proximity Read ↗

A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell ProliferationSemantic proximity Read ↗

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