Article
Patched 1 conditional null allele in mice.
Genesis (New York, N.Y. : 2000) - 1 Jul 2003
Ellis Tammy, Smyth Ian, Riley Emily, Graham Scott, Elliot Kate, Narang Monica, Kay Graham F, Wicking Carol, Wainwright Brandon
Abstract excerpt
The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, Ptc and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the Ptc gene leads to developmental defects and an embryonic lethal phenotype....
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