Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hedgehog signaling in the Drosophila eye and head: an analysis of the effects of different patched trans-heterozygotes.

Genetics - 1 Dec 2003

Thomas Chloe, Ingham Philip W

Abstract excerpt

Characterization of different alleles of the Hedgehog receptor patched (ptc) indicates that they can be grouped into several classes. Most mutations result in complete loss of Ptc function. However, missense mutations located within the putative sterol-sensing domain (SSD) or C terminus of ptc encode antimorphic proteins that are unable to repress Smo activity and inhibit wild-type Ptc from doing so, but retain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Body Patterning
Share to Cell Death

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

Share to Receptors, G-Protein-Coupled

Share to Smoothened Receptor

Source

Open in PubMed Open full text

Identifiers

PMID: 14704176
DOI: 10.1093/genetics/165.4.1915
PMCID: PMC1462905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hedgehog signaling in the Drosophila eye and head: an analysis of the effects of different patched trans-heterozygotes.PMID 14704176Read ↗

Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs.Semantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.Semantic proximity Read ↗

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking.Semantic proximity Read ↗

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.Semantic proximity Read ↗

Hedgehog pathway members Patched and Costal-2 exhibit differences in overgrowth autonomy in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.Semantic proximity Read ↗

Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched.Semantic proximity Read ↗

Non-cell autonomous inhibition of the Hedgehog response due to impaired cholesterol synthesis requires Ptch1/2 functionSemantic proximity Read ↗

Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila.Semantic proximity Read ↗

Patched and Costal-2 mutations lead to differences in tissue overgrowth autonomy.Semantic proximity Read ↗

Altered neural cell fates and medulloblastoma in mouse patched mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.