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Article

Polymorphisms in genes involved in folate metabolism as risk factors for NTDs.

European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie - 1 Dec 2001

De Marco P, Calevo M G, Moroni A, Arata L, Merello E, Cama A, Finnell R H, Andreussi L, Capra V

Abstract excerpt

Moderate hyperhomocysteinemia in pregnant women has been associated with an increased risk of neural tube defects (NTDs). Periconceptional supplementation with multi-vitamins containing folic acid may normalize homocysteine metabolism and decrease the NTD risk. The C677 T variant of the MTHFR gene coding for a thermolabile enzyme has been described as the first genetic risk factor that accounts for a group of...

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Source

Identifiers

PMID: 11813127
DOI: 10.1055/s-2001-19739

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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