Article
Reduced folate carrier polymorphisms and neural tube defect risk.
Molecular genetics and metabolism - 1 Apr 2006
O'leary Valerie B, Pangilinan Faith, Cox Christopher, Parle-McDermott Anne, Conley Mary, Molloy Anne M, Kirke Peadar N, Mills James L, Brody Lawrence C, Scott John M
Abstract excerpt
The reduced folate carrier (RFCI) is essential for folate transport into cells. Low folate is an important cause of neural tube defects (NTDs), and a single-nucleotide polymorphism (H27R) (80G-->A) in the RFCI gene has been reported to be a NTD risk factor. We investigated H27R and a 61 bp tandem repeat polymorphism as potential risk factors for NTDs, using a large homogeneous Irish population by case/control...
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