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Article

Correlation of polymorphism of MTHFRs and RFC‐1 genes with neural tube defects in China

16 Nov 2007

Abstract excerpt

BACKGROUND: Maternal periconceptional supplementation of folate reduces the incidence of neonatal Neural Tube Defects, indicating that changes in folate metabolism play a role in formation of NTDs. The mutations on two genes involved in folate metabolism, the C677 of the MTHFR gene and the RFC-1(A80G) gene are potential risk factors of NTDs. METHODS: In this study, we analyzed the genotypic distributions and...

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PMID: 18022874
DOI: 10.1002/bdra.20416

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