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Article

Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2005

Pei Lijun, Zhu Huiping, Ren Aiguo, Li Zhiwen, Hao Ling, Finnell Richard H, Li Zhu

Abstract excerpt

BACKGROUND: There is a considerable body of data demonstrating that periconceptional supplementation of folic acid can prevent a significant proportion of neural tube defects (NTDs). At present, the mechanism by which folic acid exerts its beneficial effect remains unknown. Folate transporter genes, including the reduced folate carrier gene (RFC1), have been proposed as NTD risk factors. METHODS: The study...

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Identifiers

PMID: 15799025
DOI: 10.1002/bdra.20130

Genes

RFC1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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