Article
Characterization of benzo[a]pyrene-initiated mouse skin papillomas for Ha-ras mutations and protein kinase C levels.
Carcinogenesis - 1 Nov 1993
Colapietro A M, Goodell A L, Smart R C
Abstract excerpt
The frequency and spectrum of Ha-ras mutations in benzo[a]pyrene (B[a]P)-initiated/12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted CD-1 mouse skin papillomas were characterized by amplifying high molecular weight papilloma DNA using the polymerase chain reaction (PCR) followed by direct DNA s...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Alleles
- Animals
- Base Sequence
- Benzo(a)pyrene
- Codon
- DNA, Neoplasm
- Epidermis
- Female
- Genes, ras
- Isoenzymes
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Papilloma
- Point Mutation
- Protein Kinase C