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Article

Overexpression of a constitutively active form of c-src in skin epidermis increases sensitivity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.

Molecular carcinogenesis - 1 Mar 2002

Matsumoto Takashi, Jiang Jianghong, Kiguchi Kaoru, Carbajal Steve, Rho Okkyung, Gimenez-Conti Irma, Beltrán Linda, DiGiovanni John

Abstract excerpt

Transgenic mice were developed to study the role of c-src in epithelial tumorigenesis through targeted expression of a constitutively active form of murine c-src (src(529)). Src(529) was targeted to the interfollicular epidermis with the human keratin 1 (HK1) promoter. The skin phenotype of these mice was characterized by exaggerated epidermal hyperplasia and hyperkeratosis within the first week after birth. The...

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Identifiers

PMID: 11870880
DOI: 10.1002/mc.10030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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