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Article

Mistranslation induced by streptomycin provokes a RecABC/RuvABC-dependent mutator phenotype in Escherichia coli cells.

Journal of molecular biology - 25 Jan 2002

Balashov Sergey, Humayun M Zafri

Abstract excerpt

Translational stress-induced mutagenesis (TSM) refers to the mutator phenotype observed in Escherichia coli cells expressing a mutant allele (mutA or mutC) of the glycine tRNA gene glyV (or glyW). Because of an anticodon mutation, expression of the mutA allele results in low levels of Asp-->Gly mistranslation. The mutA phenotype does not require lexA-regulated SOS mutagenesis functions, and appears to be...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Codon, Nonsense
DNA Helicases
DNA-Binding Proteins
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Endodeoxyribonucleases
Escherichia coli
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exodeoxyribonuclease V

Exodeoxyribonucleases

Gene Expression Regulation, Bacterial

Gene Frequency

Lac Operon

Mutagenesis

Phenotype

Protein Biosynthesis

Source

Identifiers

PMID: 11812126
DOI: 10.1006/jmbi.2001.5273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Mistranslation induced by streptomycin provokes a RecABC/RuvABC-dependent mutator phenotype in Escherichia coli cells.PMID 11812126Read ↗

Expression of mutant alanine tRNAs increases spontaneous mutagenesis in Escherichia coli.Semantic proximity Read ↗

Escherichia coli cells exposed to streptomycin display a mutator phenotype.Semantic proximity Read ↗

The mutA mistranslator tRNA-induced mutator phenotype requires recA and recB genes, but not the derepression of lexA-regulated functions.Semantic proximity Read ↗

Specificity of spontaneous mutations induced in mutA mutator cells.Semantic proximity Read ↗

Mistranslation and genetic variability: the effect of streptomycin.Semantic proximity Read ↗

Escherichia coli cells bearing a ribosomal ambiguity mutation in rpsD have a mutator phenotype that correlates with increased mistranslation.Semantic proximity Read ↗

Mistranslation of the genetic code by a new family of bacterial transfer RNAs.Semantic proximity Read ↗

Error-prone and error-restrictive mutations affecting ribosomal protein S12.Semantic proximity Read ↗

Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli.Semantic proximity Read ↗

DNA polymerase III from Escherichia coli cells expressing mutA mistranslator tRNA is error-prone.Semantic proximity Read ↗

Identification of mutator genes and mutational pathways in Escherichia coli using a multicopy cloning approach.Semantic proximity Read ↗

Escherichia coli cells expressing a mutant glyV (glycine tRNA) gene have a UVM-constitutive phenotype: implications for mechanisms underlying the mutA or mutC mutator effect.Semantic proximity Read ↗

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