Article
Mistranslation and genetic variability: the effect of streptomycin.
Mutation research - 10 Oct 2006
Nagel Rosa, Chan Ana
Abstract excerpt
Streptomycin is an aminoglycoside antibiotic that acts at the level of protein synthesis. Exposure to sublethal concentrations of this antibiotic increased significantly the number of Arg+ mutants derived from an Escherichia coli argE3 (ochre) rpsL31 (streptomycin-resistant) strain. The vast majority of these mutants appeared on selective minimal medium plates with streptomycin (200 micro g/ml) during stationary...
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