Article
Escherichia coli cells exposed to streptomycin display a mutator phenotype.
Journal of bacteriology - 1 Feb 1999
Ren L, Rahman M S, Humayun M Z
Abstract excerpt
Mistranslation mediated by the mutA and mutC tRNA alleles elicits a strong mutator phenotype (H. S. Murphy and M. Z. Humayun, J. Bacteriol. 179:7507-7514, 1997; M. M. Slupska, C. Baikalov, R. Lloyd, and J. H. Miller, Proc. Natl. Acad. Sci. USA 93:4380-4385, 1996). Here, we show that exposure to streptomycin, an antibiotic known to promote mistranslation, induces a recA- and umuDC-independent mutator phenotype...
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