Head-to-tail regulation is critical for the in vivo function of myosin V.

Abstract excerpt

Cell organization requires regulated cargo transport along cytoskeletal elements. Myosin V motors are among the most conserved organelle motors and have been well characterized in both yeast and mammalian systems. Biochemical data for mammalian myosin V suggest that a head-to-tail autoinhibitory interaction is a primary means of regulation, but the in vivo significance of this interaction has not been studied....

Topics

• Cell Nucleus
• Mitochondria
• Mutation
• Myosin Heavy Chains
• Myosin Type V
• Saccharomyces cerevisiae
• Saccharomyces cerevisiae Proteins
• Secretory Vesicles