Article
Step-size is determined by neck length in myosin V.
Biochemistry - 13 Dec 2005
Sakamoto Takeshi, Yildez Ahmet, Selvin Paul R, Sellers James R
Abstract excerpt
The highly processive motor, myosin V, has an extremely long neck containing six calmodulin-binding IQ motifs that allows it to take multiple 36 nm steps corresponding to the pseudo-repeat of actin. To further investigate how myosin V moves processively on actin filaments, we altered the length of the neck by adding or deleting IQ motifs in myosin constructs lacking the globular tail domain. These myosin V IQ...
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