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Article

Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Demirov Dimiter G, Ono Akira, Orenstein Jan M, Freed Eric O

Abstract excerpt

Efficient budding of HIV-1 from the plasma membrane of infected cells requires the function of a 6-kDa protein known as p6. A highly conserved Pro-Thr-Ala-Pro (PTAP) motif (the "late" or "L" domain), is critical for the virus-budding activity of p6. Recently, it was demonstrated that the product of tumor susceptibility gene 101 (TSG101), which contains at its N terminus a domain highly related to...

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Identifiers

PMID: 11805336
DOI: 10.1073/pnas.032511899
PMCID: PMC117412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function.PMID 11805336Read ↗

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