Article
RNA Binding Suppresses Tsg101 Recognition of Ub-Modified Gag and Facilitates Recruitment to the Plasma Membrane.
Viruses - 15 Apr 2020
Watanabe Susan M, Strickland Madeleine, Tjandra Nico, Carter Carol A
Abstract excerpt
The ESCRT-I factor Tsg101 is essential for sorting endocytic cargo and is exploited by viral pathogens to facilitate egress from cells. Both the nucleocapsid (NC) domain and p6 domain in HIV-1 Gag contribute to recruitment of the protein. However, the role of NC is unclear when the P(S/T)AP motif in p6 is intact, as the motif recruits Tsg101 directly. The zinc fingers in NC bind RNA and membrane and are critical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.