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Article

Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag.

Viruses - 25 Apr 2016

Friedrich Melanie, Setz Christian, Hahn Friedrich, Matthaei Alina, Fraedrich Kirsten, Rauch Pia, Henklein Petra, Traxdorf Maximilian, Fossen Torgils, Schubert Ulrich

Abstract excerpt

The HIV-1 Gag p6 protein regulates the final abscission step of nascent virions from the cell membrane by the action of its two late (L-) domains, which recruit Tsg101 and ALIX, components of the ESCRT system. Even though p6 consists of only 52 amino acids, it is encoded by one of the most polymorphic regions of the HIV-1 gag gene and undergoes various posttranslational modifications including sumoylation,...

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Share to Calcium-Binding Proteins
Share to Endosomal Sorting Complexes Required for Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to Protein Interaction Domains and Motifs

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Source

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Identifiers

PMID: 27120610
DOI: 10.3390/v8040117
PMCID: PMC4848609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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