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Article

Defects in human immunodeficiency virus budding and endosomal sorting induced by TSG101 overexpression.

Journal of virology - 1 Jun 2003

Goila-Gaur Ritu, Demirov Dimiter G, Orenstein Jan M, Ono Akira, Freed Eric O

Abstract excerpt

Retrovirus budding is greatly stimulated by the presence of Gag sequences known as late or L domains. The L domain of human immunodeficiency virus type 1 (HIV-1) maps to a highly conserved Pro-Thr-Ala-Pro (PTAP) sequence in the p6 domain of Gag. We and others recently observed that the p6 PTAP motif interacts with the cellular endosomal sorting protein TSG101. Consistent with a role for TSG101 in virus release,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12743307
DOI: 10.1128/jvi.77.11.6507-6519.2003
PMCID: PMC155030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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