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Article

Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding.

Journal of cell science - 1 May 2004

Blot Vincent, Perugi Fabien, Gay Bernard, Prévost Marie-Christine, Briant Laurence, Tangy Frédéric, Abriel Hugues, Staub Olivier, Dokhélar Marie-Christine, Pique Claudine

Abstract excerpt

One of the most exciting recent developments in the field of retroviruses is the finding that their Gag proteins hijack cellular proteins from the mutivesicular body (MVB) pathway during the budding process. The Gag proteins of oncoretroviruses possess a PPxY motif that recruits a ubiquitin ligase from the Nedd4 family, whereas those of the human immunodeficiency virus interact through a PTAP motif with Tsg101, a...

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Identifiers

PMID: 15126635
DOI: 10.1242/jcs.01095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding.PMID 15126635Read ↗

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