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Article

Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly.

Journal of virology - 1 Apr 1998

Yu X F, Dawson L, Tian C J, Flexner C, Dettenhofer M

Abstract excerpt

One of the crucial steps in the assembly of the human immunodeficiency virus type 1 (HIV-1) and other retroviruses is the incorporation and retention of all the key viral enzymes in released virions. The viral enzymes protease, reverse transcriptase, and integrase of HIV-1 are initially synthesized as Gag-Pol fusion polyproteins. It has been shown that the incorporation of Gag-Pol polyproteins during virus...

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Identifiers

PMID: 9525672
DOI: 10.1128/JVI.72.4.3412-3417.1998
PMCID: PMC109837

Genes

APP

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Source receipt: pubmed, retrieved 7 Sept 2026.

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