Article
Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk.
International journal of cancer - 1 Feb 2002
Zavras Athanasios I, Wu Tianxia, Laskaris George, Wang Yue-Fen, Cartsos Vassiliki, Segas John, Lefantzis Dimitris, Joshipura Kaumudi, Douglass Chester W, Diehl Scott R
Abstract excerpt
We investigated effects on oral cancer (OC) risk of an interaction between a single nucleotide polymorphism (SNP) in the alcohol dehydrogenase 3 (ADH3) gene and alcohol consumption levels using a hospital-based study of 93 cases and 99 controls conducted in Athens, Greece. This SNP affects ethanol metabolism in vitro and appeared to interact with alcohol consumption in a previous OC study. We also evaluated a SNP...
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