Article
Interaction between the ADH1C polymorphism and maternal alcohol intake in the risk of nonsyndromic oral clefts: an evaluation of the contribution of child and maternal genotypes.
Birth defects research. Part A, Clinical and molecular teratology - 1 Feb 2005
Chevrier Cécile, Perret Claire, Bahuau Michel, Nelva Agnès, Herman Christine, Francannet Christine, Robert-Gnansia Elisabeth, Cordier Sylvaine
Abstract excerpt
BACKGROUND: Maternal alcohol consumption has been associated with an increased risk of nonsyndromic oral clefts in some studies. Study of gene-environment interaction may provide insight into the reasons for their discrepancies observed. We focused on a polymorphism of the ADH1C gene (third gene of the class I alcohol dehydrogenase family), involved in the metabolism of ethanol and other alcohols. METHODS: Data...
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