Article
Oral cancer and polymorphism of ethanol metabolising genes.
Oral oncology - 1 Jan 2010
Marichalar-Mendia Xabier, Rodriguez-Tojo Maria J, Acha-Sagredo Amelia, Rey-Barja Natalia, Aguirre-Urizar Jose M
Abstract excerpt
Oral cancer is the sixth most common cancer worldwide and a major health problem in some parts of the world. Epidemiological studies have shown that habitual alcohol consumption could be a risk factor in oral carcinogenesis, although the true involvement of alcohol is unknown. Via alcohol dehydrogenase (ADH) and cytochrome P450 oxidase (CYP) alcohol is metabolized to acetaldehyde, a highly toxic compound, which...
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