Article
Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2001
Schwartz S M, Doody D R, Fitzgibbons E D, Ricks S, Porter P L, Chen C
Abstract excerpt
Heavy alcohol consumption, particularly in combination with cigarette smoking, increases the risk of oral squamous cell carcinoma (OSCC). Alcohol dehydrogenase 3 (ADH3) converts ethanol to acetaldehyde, which is a suspected oral carcinogen. The ADH3*1 allele is associated with increased conversion of ethanol to acetaldehyde, but whether the risk of OSCC is increased among ADH3*1 carriers, or whether the risk of...
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