Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract.

International journal of cancer - 1 Sept 2000

Bouchardy C, Hirvonen A, Coutelle C, Ward P J, Dayer P, Benhamou S

Abstract excerpt

Alcohol is a recognized risk factor for upper aerodigestive tract (UAT) cancers, but the mechanism by which alcohol causes cancer remains obscure. Ethanol is oxidized to acetaldehyde (the suspected carcinogenic agent in alcohol) by alcohol dehydrogenases (ADHs) and cytochrome P-4502E1 (CYP2E1), both of which exhibit great inter-individual variability in activity. The hypothesis that these polymorphisms influence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Aldehyde Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Cocarcinogenesis

Share to Cytochrome P-450 CYP2E1

Share to Laryngeal Neoplasms

Share to Mouth Neoplasms

Share to Smoking

Source

Identifiers

PMID: 10925369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract.PMID 10925369Read ↗

Alcohol Consumption, ALDH2 Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and PrognosisSemantic proximity Read ↗

Alcohol dehydrogenase 3 genotype as a risk factor for upper aerodigestive tract cancers.Semantic proximity Read ↗

Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy.Semantic proximity Read ↗

Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers.Semantic proximity Read ↗

Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma.Semantic proximity Read ↗

Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.Semantic proximity Read ↗

Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.Semantic proximity Read ↗

Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian population.Semantic proximity Read ↗

The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.Semantic proximity Read ↗

Multiple ADH genes are associated with upper aerodigestive cancers.Semantic proximity Read ↗

Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis.Semantic proximity Read ↗

Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.