Article
Activation mechanism of solubilized epidermal growth factor receptor tyrosine kinase.
Biochemical and biophysical research communications - 25 Jan 2002
Ge Gaoxiang, Wu Jing, Wang Yan, Lin Qishui
Abstract excerpt
Dimerization of epidermal growth factor receptor (EGFR) leads to the activation of its tyrosine kinase. To elucidate whether dimerization is responsible for activation of the intracellular tyrosine kinase domain or just plays a role in the stabilization of the active form, the activated status of wild-type EGFR moiety in the heterodimer with kinase activity-deficient mutant receptors was investigated. The kinase...
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