Article
Epidermal growth factor receptor: association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand.
Growth factors (Chur, Switzerland) - 1 Mar 2003
Zhu Hong-Jian, Iaria Josephine, Orchard Suzanne, Walker Francesca, Burgess Antony W
Abstract excerpt
The epidermal growth factor receptor (EGFR) plays an important role in many types of human cancers. Receptor amplification, autocrine activation and/or deletion of exons 2-7 of EGFR gene have all been associated with tumor development. The traditional model of EGFR activation via ligand induced dimerization and consequential kinase activation does not provide full understanding of its tumorigenicity. The main...
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