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Article

EGFR forms ligand-independent oligomers that are distinct from the active state.

The Journal of biological chemistry - 18 Sept 2020

Byrne Patrick O, Hristova Kalina, Leahy Daniel J

Abstract excerpt

The human epidermal growth factor receptor (EGFR/ERBB1) is a receptor tyrosine kinase (RTK) that forms activated oligomers in response to ligand. Much evidence indicates that EGFR/ERBB1 also forms oligomers in the absence of ligand, but the structure and physiological role of these ligand-independent oligomers remain unclear. To examine these features, we use fluorescence microscopy to measure the oligomer...

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Identifiers

PMID: 32727847
DOI: 10.1074/jbc.RA120.012852
PMCID: PMC7504936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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