Article
Detection of usual and atypical aldehyde dehydrogenase alleles by mismatch amplification mutation assay.
Clinical chemistry and laboratory medicine - 1 Dec 2001
Luo H R, Tu G C, Zhang Y P
Abstract excerpt
The genotypes of liver mitochondrial high-affinity aldehyde dehydrogenase-2 (ALDH2) are strongly associated with the drinking behavior and the alcohol liver diseases, since the individuals with atypical ALDH2(2) allele have higher levels of acetaldehyde in their plasma. The atypical ALDH2(2) allele has a nucleotide base transition (G-->A) in its exon 12. Based on this point mutation, we developed a rapid,...
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