Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency.

doi:10.1007/BF02782812

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Article

Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency.

Gastroenterologia Japonica - 1 Aug 1991

Enomoto N, Takada A, Date T

Abstract excerpt

About half of all Japanese lack the activity of aldehyde dehydrogenase 2 (ALDH2), and suffer a flush after alcohol intake due to the marked elevation of blood acetaldehyde concentration. The cause of ALDH2 deficiency is thought to be a single point mutation in codon 487 of the ALDH2 gene. However...

Topics

Aldehyde Dehydrogenase
Exons
Female
Genes, Dominant
Genotype
Humans
Liver Diseases, Alcoholic
Male
Mutation
Oligonucleotide Probes
Polymerase Chain Reaction

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