Genetic Polymorphisms of the Mitochondrial Aldehyde Dehydrogenase ALDH2 Gene in a Large Ethnic Hakka Population in Southern China.

doi:10.12659/msm.906606

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Genetic Polymorphisms of the Mitochondrial Aldehyde Dehydrogenase ALDH2 Gene in a Large Ethnic Hakka Population in Southern China.

Medical science monitor : international medical journal of experimental and clinical research - 6 Apr 2018

Zhong Zhixiong, Hou Jingyuan, Li Bin, Zhang Qifeng, Li Cunren, Liu Zhidong, Yang Min, Zhong Wei, Zhao Pingsen

Abstract excerpt

BACKGROUND Human mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a critical role in the detoxification of the ethanol metabolite acetaldehyde. The ALDH2*2 (rs671) gene variant is mainly absent among Europeans but is prevalent in populations in East Asia. The aim of this study was to investigate ALDH2*2 mutant alleles and genotype frequencies in the Hakka population of China. MATERIAL AND METHODS Between...

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PMID: 29623947
DOI: 10.12659/msm.906606
PMCID: PMC5903313

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ALDH2

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