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Article

A new approach for the rapid detection of common and atypical aldehyde dehydrogenase alleles.

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies - 1 Sept 1993

Tu G C, Israel Y

Abstract excerpt

A strong protection against the development of alcoholism is exerted by a point mutation in the gene coding for low Km aldehyde dehydrogenase (ALDH), i.e. ALDH2. We report a non-radioactive method for determining the common and atypical human mitochondrial aldehyde dehydrogenase (ALDH2) genotypes. This method is based on the fact that the base change (G-->A) in Exon 12 of the ALDH2 gene abolishes an Eco57 I...

Topics

Alcoholism
Aldehyde Dehydrogenase
Alleles
Base Sequence
Electrophoresis, Agar Gel
Ethidium
Exons
Genotype
Humans
Mitochondria
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Point Mutation

Polymerase Chain Reaction

Source

Identifiers

PMID: 8260531
DOI: 10.1515/cclm.1993.31.9.591

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8260531-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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