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Article

Intact follicular maturation and defective luteal function in mice deficient for cyclin- dependent kinase-4.

Endocrinology - 1 Feb 2002

Moons David S, Jirawatnotai Siwanon, Tsutsui Tateki, Franks Roberta, Parlow A F, Hales Dale B, Gibori Geula, Fazleabas Asgerally T, Kiyokawa Hiroaki

Abstract excerpt

Cell cycle progression of granulosa cells is critical for ovarian function, especially follicular maturation. During follicular maturation, FSH induces cyclin D2, which promotes G1 progression by activating cyclin-dependent kinase-4 (Cdk4). Because cyclin D2-deficient mice exhibit a block in follicular growth, cyclin D2/Cdk4 has been hypothesized to be required for FSH-dependent proliferation of granulosa cells....

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Identifiers

PMID: 11796521
DOI: 10.1210/endo.143.2.8611

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PRL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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