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Article

LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice

2 Dec 2015

Abstract excerpt

Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II. Meiotic progression is controlled by CDK1 activity and is accompanied by dynamic epigenetic changes. Although the signalling pathways regulating CDK1 activity are well defined, the functional significance of epigenetic changes remains largely unknown. Here we show that...

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PMID: 26626423
DOI: 10.1038/ncomms10116

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