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CDK4: A Key Player in the Cell Cycle, Development, and Cancer

1 Nov 2012

Abstract excerpt

The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates progression through the G1 phase when the cell prepares to initiate DNA synthesis. Although CDK4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this...

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PMID: 23634254
DOI: 10.1177/1947601913478972

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