Article
Correlation of CYP2C19 genotype with plasma voriconazole levels: a preliminary retrospective study in Indians.
International journal of clinical pharmacy - 1 Oct 2015
Chawla Prerna K, Nanday Shweta R, Dherai Alpa J, Soman Rajeev, Lokhande Rohan V, Naik Prasad R, Ashavaid Tester F
Abstract excerpt
BACKGROUND: Voriconazole is an antifungal drug essentially metabolized by cytochrome P450 (CYP2C19) isozyme. Plasma voriconazole levels exhibit wide inter-individual variability due to several factors like age, weight, food or drug interactions or CYP2C19 polymorphisms. OBJECTIVE: In the present study, we assessed the correlation of voriconazole levels with CYP2C19 genotype in patients on voriconazole therapy....
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