Article
A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA.
Nucleic acids research - 15 Jan 2002
Chen Jiunn-Liang, Opperman Kay Keyer, Greider Carol W
Abstract excerpt
Telomerase is an enzyme that maintains telomere length by adding telomeric sequence repeats onto chromosome ends. The telomerase ribonucleoprotein complex consists of two essential components, a reverse transcriptase and an RNA molecule that provides the template for telomeric repeat synthesis. A common secondary structure of vertebrate telomerase RNA has been proposed based on a phylogenetic comparative analysis...
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