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Article

Structural features of mouse telomerase RNA are responsible for the lower activity of mouse telomerase versus human telomerase.

The Biochemical journal - 1 Aug 2006

Garforth Scott J, Wu Yan Yun, Prasad Vinayaka R

Abstract excerpt

Human and mouse telomerases show a high degree of similarity in both the protein and RNA components. Human telomerase is more active and more processive than the mouse telomerase. There are two key differences between hTR [human TR (telomerase RNA)] and mTR (mouse TR) structures. First, the mouse telomerase contains only 2 nt upstream of its template region, whereas the human telomerase contains 45 nt. Secondly,...

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Identifiers

PMID: 16669789
DOI: 10.1042/BJ20060456
PMCID: PMC1533308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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