Article
Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington's disease.
Neuroscience - 1 Jan 2002
Clifford J J, Drago J, Natoli A L, Wong J Y F, Kinsella A, Waddington J L, Vaddadi K S
Abstract excerpt
Transgenic R6/1 mice incorporate a human genomic fragment containing promoter elements exon 1 and a portion of intron 2 of the Huntingtin gene responsible for Huntington's disease. They develop late-onset neurological deficits in a manner similar to the motor abnormalities of the disorder. As essential fatty acids are phospholipid components of cell membranes which may influence cell death and movement disorder...
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