Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.

Brain : a journal of neurology - 1 Apr 2009

Pouladi Mahmoud A, Graham Rona K, Karasinska Joanna M, Xie Yuanyun, Santos Rachelle Dar, Petersén Asa, Hayden Michael R

Abstract excerpt

Huntington disease is a neurodegenerative disorder caused by an expanded CAG repeat in the Huntington disease gene. The symptomatic phase of the disease is defined by the onset of motor symptoms. However, psychiatric disturbances, including depression, are common features of Huntington disease an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Body Weight
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntingtin Protein

Share to Huntington Disease

Share to Sex Factors

Share to Swimming

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 19224899
DOI: 10.1093/brain/awp006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19224899-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin.PMID 19224899Read ↗

A Tale of Two Maladies? Pathogenesis of Depression with and without the Huntington’s Disease Gene MutationSemantic proximity Read ↗

BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice.Semantic proximity Read ↗

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington diseaseSemantic proximity Read ↗

Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease.Semantic proximity Read ↗

Huntington's disease.Semantic proximity Read ↗

Antisense oligonucleotide-mediated disruption of HTT caspase-6 cleavage site ameliorates the phenotype of YAC128 Huntington disease mice.Semantic proximity Read ↗

Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease.Semantic proximity Read ↗

Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice.Semantic proximity Read ↗

Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington's disease.Semantic proximity Read ↗

Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease.Semantic proximity Read ↗

Specific psychiatric manifestations among preclinical Huntington disease mutation carriers.Semantic proximity Read ↗

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.