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Article

XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent.

PloS one - 1 Jan 2018

Polyzos Aris A, Wood Nigel I, Williams Paul, Wipf Peter, Morton A Jennifer, McMurray Cynthia T

Abstract excerpt

We have reported that the radical scavenger XJB-5-131 attenuates or reverses progression of the disease phenotype in the HdhQ(150/150) mouse, a slow onset model of HD. Here, we tested whether XJB-5-131 has beneficial effects in R6/2 mice, a severe early onset model of HD. We found that XJB-5-131 has beneficial effects in R6/2 mice, by delaying features of the motor and histological phenotype. The impact was...

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Identifiers

PMID: 29630611
DOI: 10.1371/journal.pone.0194580
PMCID: PMC5890981

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