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Article

Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models.

Human molecular genetics - 15 Mar 2009

Phan Jack, Hickey Miriam A, Zhang Peixiang, Chesselet Marie-Francoise, Reue Karen

Abstract excerpt

In addition to the hallmark neurological manifestations of Huntington's disease (HD), weight loss with metabolic dysfunction is often observed in the later stages of disease progression and is associated with poor prognosis. The mechanism for weight loss in HD is unknown. Using two mouse models of HD, the R6/2 transgenic and CAG140 knock-in mouse strains, we demonstrate that adipose tissue dysfunction is...

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PMID: 19124532
DOI: 10.1093/hmg/ddn428
PMCID: PMC2649017

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PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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