Article
The Gli2 transcription factor is required for normal mouse mammary gland development.
Developmental biology - 1 Oct 2001
Lewis M T, Ross S, Strickland P A, Sugnet C W, Jimenez E, Hui C, Daniel C W
Abstract excerpt
The hedgehog signal transduction network performs critical roles in mediating cell-cell interactions during embryogenesis and organogenesis. Loss-of-function or misexpression mutation of hedgehog network components can cause birth defects, skin cancer, and other tumors. The Gli gene family (Gli1, Gli2, and Gli3) encodes zinc finger transcription factors that act as mediators of hedgehog signal transduction. In...
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