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Article

Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure.

The Journal of biological chemistry - 7 Dec 2007

Fiaschi Marie, Rozell Björn, Bergström Asa, Toftgård Rune, Kleman Marika I

Abstract excerpt

The Hedgehog signaling pathway regulates the development and function of numerous tissues and when mis-regulated causes tumorigenesis. To assess the role of a deregulated Hedgehog signaling pathway in the mammary gland we targeted the expression of the Hedgehog effector protein, GLI1, to mammary epithelial cells using a bigenic inducible system. A constitutively active Hedgehog signaling pathway resulted with...

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Identifiers

PMID: 17928300
DOI: 10.1074/jbc.M704280200

Genes

GLI1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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