GLI transcription factors: mediators of oncogenic Hedgehog signalling.

doi:10.1016/j.ejca.2005.08.039

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Article

GLI transcription factors: mediators of oncogenic Hedgehog signalling.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2006

Kasper Maria, Regl Gerhard, Frischauf Anna-Maria, Aberger Fritz

Abstract excerpt

The current concept of tumourigenesis holds that cancer results from the progressive acquisition of mutations that endow affected cells with selective growth advantages by activating multiple processes including intrinsic mitogenic and pro-survival pathways. Constitutive activation of the Hedgehog (HH)/GLI signalling cascade has recently been implicated in the growth of a number of human malignancies ranging from...

Topics

Carrier Proteins
Humans
Membrane Glycoproteins
Mutation
Neoplasms
Oncogenes
Signal Transduction
Transcription Factors
Zinc Finger Protein GLI1

Source

Open in PubMed

Identifiers

PMID: 16406505
DOI: 10.1016/j.ejca.2005.08.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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