Article
Dominant activation of the hedgehog signaling pathway alters development of the female reproductive tract.
Genesis (New York, N.Y. : 2000) - 1 Jan 2012
Migone Fernando F, Ren Yi, Cowan Robert G, Harman Rebecca M, Nikitin Alexander Yu, Quirk Susan M
Abstract excerpt
The role of hedgehog (HH) signaling in reproductive tract development was studied in mice in which a dominant active allele of the signal transducer smoothened (SmoM2) was conditionally expressed in the Müllerian duct and ovary. Mutant females are infertile, primarily because they fail to ovulate. Levels of mRNA for targets of HH signaling, Gli1, Ptch1, and Hhip, were elevated in reproductive tracts of 24-day-old...
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