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Article

Sickle Cell Hemoglobin with Mutation at αHis-50 Has Improved Solubility.

The Journal of biological chemistry - 28 Aug 2015

Tam Ming F, Tam Tsuey Chyi S, Simplaceanu Virgil, Ho Nancy T, Zou Ming, Ho Chien

Abstract excerpt

The unliganded tetrameric Hb S has axial and lateral contacts with neighbors and can polymerize in solution. Novel recombinants of Hb S with single amino acid substitutions at the putative axial (recombinant Hb (rHb) (βE6V/αH20R) and rHb (βE6V/αH20Q)) or lateral (rHb (βE6V/αH50Q)) or double amino acid substitutions at both the putative axial and lateral (rHb (βE6V/αH20R/αH50Q) and rHb (βE6V/αH20Q/αH50Q)) contact...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26187468
DOI: 10.1074/jbc.M115.658054
PMCID: PMC4571898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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