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Article

Role of beta87 Thr in the beta6 Val acceptor site during deoxy Hb S polymerization.

Biochemistry - 16 Dec 1997

Reddy L R, Reddy K S, Surrey S, Adachi K

Abstract excerpt

Three new Hb S variants containing beta87 Leu, Trp, or Asp instead of Thr were expressed in yeast in order to further define the role of the beta87 position in stability and polymerization of deoxy Hb S. Previous studies showed that hydrophobicity at beta85 Phe and beta88 Leu is critical for stabilization of hemoglobin. Results with the three Hb S beta87 variants, however, showed minimal differences in stability,...

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Identifiers

PMID: 9398334
DOI: 10.1021/bi9717439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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